Publications & Studies

Our testing methodologies are backed by Peer Reviewed, Published and independent validation studies Establishing the Clinical Utility of our tests. We believe in science you can trust for clinical decision-making—and we make that science available for your review.

Doc Lab Publications

Spangler, F.L.; Williams, C.; Aberger, M.E.; Wilson, B.A.; Ajib, K.; Gholami, S.S.; Goodwin, H.N.; Park, L.Y.; Kardjadj, M.; Derrick, D.; et al. Clinical utility of PCR compared to conventional culture and sensitivity testing for the management of complicated urinary tract infections in adults: Part I: Assessment of clinical outcomes, investigator satisfaction scores, and turnaround times. Diagn. Microbiol. Infect. Dis. 2025, 111, 116601.

Spangler, F.L.; Williams, C.; Aberger, M.E.; Wilson, B.A.; Ajib, K.; Gholami, S.S.; Goodwin, H.N.; Park, L.Y.; Kardjadj, M.; Derrick, D.; et al. Clinical utility of PCR compared to conventional culture and sensitivity testing for management of complicated urinary tract infections in adults: Part II: Evaluation of diagnostic concordance, discordant results, and anti- microbial selection efficacy. Diagn. Microbiol. Infect. Dis. 2025, 111, 116646

Kardjadj, M.; Chang, T.W.; Chavez, R.; Derrick, D.; Spangler, F.L.; Priestly, I.P.; Park, L.Y.; Huard, T.K. The clinical validity and utility of PCR compared to conventional culture and sensitivity testing for the management of complicated urinary tract infections in adults: A secondary (ad hoc) analysis of pathogen detection, resistance profiles, and impact on clinical outcomes. Microorganisms 2025, 13, 949.

Aberger, M.E.; Wilson, B.A.; Chavez, R. Evaluating the analytical validity and clinical utility and validity of polymerase chain reaction diagnostics vs culture and sensitivity methods in complicated urinary tract infection management: A comprehensive review of real-world evidence, clinical trials, and meta-analyses concerning molecular diagnostic services program coverage criteria. Rev. Urol. 2025, 24, 1–11.

Kardjadj, M. Clinical Utility of PCR in Complicated Urinary Tract Infections: A Paradigm Shift in Diagnostics and Management. JU Open Plus 2025, 3, e00114.

Semi-Quantitative ΔCt Thresholds for Bacteriuria and Pre-Analytic Drivers of PCR-Culture Discordance in Complicated UTI: An Analysis of NCT06996301

Genotype–Phenotype Concordance and Ct-Informed Predictive Rules for Antimicrobial Resistance in Adult Patients with Complicated Urinary Tract Infections: Clinical and Stewardship Implications from the NCT06996301 Trial

Clinical Symptom Resolution Following PCR-Guided vs. Culture and Susceptibility-Guided Management of Complicated UTI: How Time-To-Antibiotic Start and Antibiotic Appropriateness Mediate the Benefit of Multiplex PCR—An Ad Hoc Analysis of NCT06996301